Initially a singer for an indie band, LiSA made her major debut in 2010 as one of the two vocalists for the anime Angel Beats!. She later appeared at Animelo Summer Live in August 2010. In April 2011, she made her solo debut with the release of Letters to U. Most recently, she released her seventh single Shirushi, which is used as the second ending theme to Sword Art Online II.
Throughout her career, she has sold out the Nippon Budokan three times and also performed overseas in Singapore, Taipei, Hong Kong, Indonesia, Thailand and the United States.